AMACR聯(lián)合34βE12、p63在前列腺癌診斷和鑒別診斷中的作用.pdf

1、青島大學碩士學位論文AMACR聯(lián)合34βE12、p63在前列腺癌診斷和鑒別診斷中的作用姓名：林濤申請學位級別：碩士專業(yè)：外科學（泌尿外科）指導教師：王友寶孫立江20080531ThevalueofAMACRcombinedwithCK3413E12andp63immunotainingforthediagnosisanddifferentialdiagnosisofprostatecancerAbstractobjeetiveToeva

2、luatetheValueofthenewtumormarkerAMACRcombinedwithCK34pE12andp63immunotainingforthediagnosisanddifferentialdiagnosisofprostatecancer；tohaveallunderstandingofthecorrelationbetweentheexpressionofAMACRandtheclassificationofp

3、rostatecancerandtheexpressionofPSA：tohaveapreliminarydiscussionofthemechanismofAMACRi11theoccurrenceofprostatecancerMethodsImmunohistochemistrywasusedtodetecttheexpressionofAMACR、3413E12、p63andPSAinprostatecancer(Pea)、pa

4、raneoplasticnormaltissue、benignprostatehyperplasia(BPH)、HGPINandAAHThenwestatisticsthepositiveexpressionrateofAMACR、34pE12andp63inabovementionedtissue。analysethevalueofAMACRinthediagnosisofprostatecancerandtherelationshi

5、psbetweentheexpressionofAMACRandtheclassificationofprostatecancerandtheexpressionofPSAinprostatetissueResultsThepositiveexpressionrateofAMACRinprostatecancer(PCa、、paraneoplasticnormaltissue、benignprostatehyperplasia(BPH)

6、、HGPINandAAHis927％(38／41)、0％、O％、40％(6／15)、111％(1／9)：ThepositiveexpressionrateofAⅣ【ACRamongthefivegroupsismarkedstatisticllysit亭nificantP001，comparedwithPCagrouptheexpressionofAMACRinHGPINgroupismarkedstatisticllysignific

7、antbotllinthepositiveexpressionrateandintensityP001Staininginbasalcellsshowtissueofprostatecancerlackofbasalcellsparaneoplasticnormaltissueandbenignprostatehyperplasia(BPH)hascontinuousbasalcellsinmostoftheglands；Tissuei

8、nHGPINandAAHhasCOntinuousorimtermittentbasalcellsTheintensityofAMACRinprostatecancerhasnorealationshipwiththeclassificationofprostatecancerandtheexpressionofPSAinprostatetissueConclusionAMACR，whichCanraisetheaccuracyofdi

9、agnosisinprostatecancercombinedwith3415E12andp63CallbeusedasaprostatecancerspecificmarkerespeciallyinthediagnosisofpuncturedsmallsampleThedetectionofAMACRCanprovidcluesandexperimentalevidencefortheproceed，developmentandt