原發(fā)性結(jié)腸黑色素瘤一例報告并文獻復(fù)習(xí).pdf

1、浙江大學(xué)醫(yī)學(xué)院碩士學(xué)位論文原發(fā)性結(jié)腸黑色素瘤一例報告并文獻復(fù)習(xí)姓名：呂一駿申請學(xué)位級別：碩士專業(yè)：腫瘤學(xué)指導(dǎo)教師：張?zhí)K展20100401浙江大學(xué)碩士學(xué)位論文英文摘要PrimaryColonicMelanoma：aCaseReportandLiteratureReviewCollegeofMedicine，ZhejiangUniversityOncologyPostgraduateⅥjullLvSupervisorProfSuzhanZh

2、angAbstractobjectiveTodiscusstheclinicalfeaturesandofprimarycolonicmelanomaMethodOnecasewasselectedfromthefilesoftheDepartmentofOntology，MedicalCollegeofZhejiangUniversityin2010Combinedwimother9casesselectedfromliteratur

3、e，therewerealtogether10casescollectedandtheirclinicaldatawereanalyzedretrospectivelyResultsMedianageWaS615yearsold，agerangefrom13—88yearsold，90％ofpatientswereolderthan40yearsoldThetunlorindghthemicolonaccounts70％ofpatien

4、tsThemainclinicalmanifestationwereabdominalpainabdominalmassmelenaconstipation，diarrhea60％ofpatientshadsymptomsofabdominalpainUsedimmunohistochemicalindicatorsare“S100，HMB45，Melan—A，VimentinEachconfirmedcasehadatleastone

5、positiveindicatorPositiverateofS一100Was889％70O％forHMB45，100％forMelan—A，100％forVimentin，556％forbothS100andHMB45Operablepatientsallunderwentsurgerywithoutadjuvanttherapy，oneadvancedstagecasetreatedbyimmunetherapynleaverage

6、diseasefreesurvivalWasmorethan346months，atleast2yearsdisease—freesurvivalrateWas857％，and429％for3yeardiseaSe—freesurvivalrateConclusionPrimarycolonicmelanomahasnospecialclinicalmanifestations，howevermostpatientscanpresent