腎移植患者皮膚膿腫中分離出糠秕馬拉色菌的臨床及實(shí)驗(yàn)研究.pdf

1、四川大學(xué)碩士學(xué)位論文腎移植患者皮膚膿腫中分離出糖秕馬拉色菌的臨床及實(shí)驗(yàn)研究姓名：趙紅梅申請學(xué)位級別：碩士專業(yè)：皮膚性病學(xué)指導(dǎo)教師：冉玉平周光平20030422腎移植患者皮肽膿腫中分離裱秕馬拉包苗的臨床披實(shí)驗(yàn)研究IsolationofMalasseziafu咖，fromtheGroinAbscessofaRenalTransplantPatient：TheFirstReportinChinaPostgraduateHongrneiZHAO

2、TutorYupingRANGuangpingZHOUobjectiveWereportherethediscoveryofMalassezia聲咖rfromagroinabscessofarenaltransplantpatientMethodsA33yearoldmalepatientwasadmittedtoourhospitalwithahi。ghfeverandaninflammatorynodulethatpersisted

3、onhisrightgroinforoneweekHehadreceivedarenaltransplant3yearsearlierandremainedonimmunosuppressiveagentsHewastreatedwithbroad—spectrumantibioticsafterhishospitalizationbutthenoduleformedalargeabscessandthenade印ulcerinstea

4、dofresolvingYeastswererecovereduponcultureofPusandnecrotictssueandthepatientreceivedoralfluconazoleandtopicalamphotericinBTheyeastisolatedfromtheabscessbeforeandafterantifungaltreatmentandthatfromthenormalskinofthepatien

5、twereidentifiedbymeansofmorphologic，biophysicalandbiochemicaltestsTheintTaspecificvariationwasalsoinvestigatedbymearlsofrandomamplifiedpolymorphicDNA(RAeD)Thepathogenicityoftheisolatesweretestedinmicebyintravenousinjecti

6、onof05x106cfupernlouseafterimmunosuppressivewith500mg／kgofprednisoneintraporitoneallyoriday一2DrugsensitivityandproteinaseactivityoftheisolateswerealsoinvestigatedResultsExaminationoftheculturebylightmicroscopyrevealedovo