立體定向放射外科治療腦轉(zhuǎn)移瘤療效及影響預(yù)后因素的研究.pdf

1、蘭州大學(xué)碩士學(xué)位論文立體定向放射外科治療腦轉(zhuǎn)移瘤療效及影響預(yù)后因素的研究姓名：劉鋒申請學(xué)位級別：碩士專業(yè)：外科學(xué)（神經(jīng)外科）指導(dǎo)教師：雷鵬20100601蘭州大學(xué)碩士學(xué)位論文EvaluationandprognosticfatcoranalysisofstereotacticradiosurgeryforbrainmatestasesAbstractObjectiveTodeterminetheoutcomeforbrainmetast

2、asespatientstreatedwithlinacbasedstereotacticradiosurgery(SRS)andevaluatethepotentialprognosticfactorsMethodsWereviewed104patientswith196brainmetastatictumorstreatedwithalinacbasedSRSfrom1999to2009，including39patientswit

3、hsolitaryand65withmultiplebrainmetastases；male69，femal35BrainlabstereotacticsystermwasappliedforthetreatmentThecenterdosewas24Gy一30Gy(median26Gy)andmargindosewas16Gy一28Gy(median165Gy)Andtheothertherapywasgivenbasedonthep

4、atient’SsituationTheCoxproportionalhazardsregressionwithunivariateandmultivariateanalysiswasperformedwithSPSS100softwareResultsDuringthefollow—up，thefocusshdnkedordisappearedin88(8462％)，keptstablein10(962％)andincreasedin

5、6(576％)Inthisseriesof104patients，thefollow—uptimewasrange1to102monthsmedianl0monthsThemediansurvivalwas12monthsafterSRS(95％CI1O28—1615)1meactuarialoverallsurvivalratewas5321％and2453％at1，2yearsrespectivelyUnivariateanalys

6、isshowedthatage，KPSscore，timeofmetastatictumor，volumeandnumberofbrainmetastases，pathologytypeoflungcancertreatmentmodalityforbrainmetastaseshadaneffectonsurvival；MultivariateanalysisshowedthatKarnofskyScore，timeofbrainme

7、tastasisandtumorvolumehadasignificantpositiveeffectonsurvivalConclusionStereotacticradiosurgeryisalleffectivetreatmentmodalityforbrainmetastasesMultiplefactorsmayaffectsurvivalofthepatientsItshowedthattheKPSscore，timeofb