BDE-209和鎘單獨(dú)及聯(lián)合暴露對非洲爪蟾的甲狀腺和生殖內(nèi)分泌的干擾作用.pdf

1、河北大學(xué)碩士學(xué)位論文BDE209和鎘單獨(dú)及聯(lián)合暴露對非洲爪蟾的甲狀腺和生殖內(nèi)分泌的干擾作用姓名：徐海明申請學(xué)位級別：碩士專業(yè)：水生生物學(xué)指導(dǎo)教師：王宏偉201105AbstractIIAbstractPBDE(PolybrominateddiphenylethersPBDEs)oneofbrominatedflameretardantswerewidelyusedinavarietyofindustries.NowadaysPBDEsh

2、avebecomeamajpersistentganicpollutant.Cadmium(Cd)contaminationlikeotherheavymetalpollutionpossessestheacteristicsofabundanceinresourceslongretentiontimecumulationtransferenrichmentalongthefoodchaindetectionrestationdiffi

3、cultyiftheenvironmenthasbeencontaminatedetc.InanimalexperimentsPBDEsCdhavebeenproventocausedevelopmentalneurotoxicitythyroidreproductiveendocrinedisruption.Inthisthesisfirstofalltherecentresearchprogressintoxicologystudy

4、onPBDEsCdisintroducedseveralproblemsinthisresearchfieldaresummarized.TheadvantagesofXenopuslaviesintoxicologystudyarediscussedintroducedtheapplicationofX.laevisinembryotoxicitythyroiddisruptionreproductiveendocrinedisrup

5、tion.ConsideringlimitedtoxicitydataonBDE209CdwhichhasbeenwidelyexistedtheeffectsofthyroidreproductiveendocrinedisruptionofsinglecombinedexposuretoBDE209(100ngL)Cd(1μgL)atenvironmentallyrelevantdosesinX.laeviswerestudied.

6、Thefinalconclusionsoftheresearcharethefollowing:(1)TheshttermexposuretoBDE209atenvironmentalrelateddosesdidnotaffectthegrowthprocessofXenopuslaevisalsodidnotaffectthedevelopmentinducedbytriiodothyronine(T3)(2)Thelongterm

7、exposuretoBDE209CdatenvironmentalrelateddoseshadthyroiddisruptingeffectsonX.laevis(3)ThelongtermexposuretoBDE209Cdatenvironmentalrelateddosesdidnotsignificantlyeffectthedevelopmentofovaries.HoweverCdsingleexposurecombine

8、dexposurecausecertaindamageonthetestesofX.laevis.InsummaryBDE209CdatenvironmentallyrelevantdoseshadthyroidreproductiveendocrinedisruptiononX.laevis.ThetoxicaleffectsmechanismsofPBDEsheavymetalinteractionremaintobefurther