1 以取代烯酮為底物的不對(duì)稱環(huán)丙烷化反應(yīng)研究;2 Indolactam-V類似物的合成研究.pdf

1、復(fù)旦大學(xué)博士學(xué)位論文1以取代烯酮為底物的不對(duì)稱環(huán)丙烷化反應(yīng)研究2IndolactamV類似物的合成研究姓名：蔣詠文申請(qǐng)學(xué)位級(jí)別：博士專業(yè)：有機(jī)化學(xué)指導(dǎo)教師：馬大為2002.5.1AbstractYongwenJiang(OrganicChemistry)Supervisor：ProfDaweiMaAsweknow，compoundsthatareabletoselectivelymodulatetheindividualPKCisozy

2、mesorsubtypesofmetabotropicglutamatereceptors(mGluRs)carlserveasvaluableresearchtoolsintheelucidationoftheirphysiologicalrolesAdditionally，suchcompoundsholdpromiseinthedevelopmentofnoveltherapeuticsforthetreatmentofhuman

3、diseases，suchascancerandAlzheimer’SdementiaL—Glutamateisthemajorexcitatoryaminoacidneurotransmitterinthecentralnervoussystemandoperatesthrou曲multipleiontropicandGproteincoupledreceptorsToseekfurtherthestructureactivity、r

4、elationshipofconformationallyconstrainedanaloguesofglutamicacid，allkindsofgeneralandefficientsyntheticmethodsarehighlydesiredInthefirstpartofthethesis，inconnectionwithoureffortsonthestudiesofselectivemodulatorsofmetabotr

5、opicglutamatereceptors，wedevelopedamethodofstereoselectivecyclopropanationofsulfoniumylideswithenonesBasedonthisreaction，wehavesucceededinsynthesizingsomebiologicallyimportant12，3一trisubstitutedcyclopropanes(conformation

6、allyconstrainedglutamicacidanalogues)suchasCCGanaloguesMeanwhile，wedrawinspirationfromthisreactionofcyclopropanationanddevelopedasyntheticmethodofenantiopuretetrasubstituteddihydrofuranThesecondpartisaboutthestudyofthesy

7、nthesisoftheanaloguesofIndolactamVWetriedtoprocessthissyntheticrouteviatheCu—catalyzedcouplingreactionofarylhalidesanda—aminoacids，butwefoundindolecompoundsarenotavailablesubstancetothisreactionWealsostudiedtheFriedel—Cr

8、aftsacylationofL—Tryptophan’SderivativesandusedL—TryptophanasastartingmaterialtosynthesizesomeanaloguesofILVAtlast，basedonthestructureofILV，wedesignedandsynthesizedtwelve—memberedringindolactamKeywords：stereoselectivecyc