復(fù)發(fā)性流產(chǎn)與HLA-DQB1基因多態(tài)性的研究.pdf

1、山西醫(yī)科大學(xué)碩士學(xué)位論文復(fù)發(fā)性流產(chǎn)與HLADQB1基因多態(tài)性的研究姓名：牛麗云申請學(xué)位級(jí)別：碩士專業(yè)：婦產(chǎn)科學(xué)指導(dǎo)教師：鄭梅玲20050520山西醫(yī)科大學(xué)焉士學(xué)位論文StudyonassociationofHLADQBlwithrecurrentspontaneousabortionABSTRACTobjective：ToinvestigatetheHLA—DQBIgenespolymorphismandfindtherelations

2、hipbetweentherecurrentspontaneousabortionandHLA—DQB1Methods：HLA—DQB1genestypingsareperformedbypolymerasechainreactionrestrictivefragmentlengthpolymorphism(PCRRFLP)techmiquein61casesofrecurrentspontaneousabortion(ofwhich3

3、1areACA()，30areACA(一)，22have2timesabortionsand39have3times，28areearlyabortions，22arelateabortionsandi1arebothearlyandlateabortions)and36womenwithoutunnormalpregnancyhistoryResult：(1)Inrecurrentspontaneousabortiongroupthe

4、frequenciesofDQBl40201allelewereincreasedhighly，butsignificantdifferencewasnotobserved(PO05)；thefrequenciesof57sitewithnonAspinRSAweremuchhigherthanthatofcontrolgroups，andsignificantdifferencewasobserved；(2)thefrequencie

5、sofDQB10303werefoundtobesignificantlyhigherinACA()thaninACA(一)(P005)；(3)thefrequenciesofDQBl0201＼0303weresignificantdifferenceamongearlyabortiongroups，lateabortiononesandbothofthem，throughfurthercomparingthefrequenciesof

6、DQBl0201wassignificentlyhigherinearlyabortiongroupsthanthatin1ateonesandthefrequenciesofDQB10303weremuchhigherinlateonesthanthathaearlyones(4)Therewasnosignificantdifferencebetweenthefrequenciesof2timesabortiongroupsand3

7、timesollesConclusion：57sitewitIlnonAspmaybesentisivegenetorecurrentspontaneousabortions；DQBl0201mayberelatedtotheearlyabortions，DQB10303mayberelatedtothelateabortionsandabortionswithACA()Keywords：recurrentspontaneousabor