ATM、DNA-PKcs在宮頸癌組織中的表達(dá)及與放療敏感性的研究.pdf

1、寧夏醫(yī)科大學(xué)碩士學(xué)位論文ATM、DNA-PKcs在宮頸癌組織中的表達(dá)及與放療敏感性的研究姓名：王秋申請學(xué)位級(jí)別：碩士專業(yè)：腫瘤學(xué)指導(dǎo)教師：折虹20100401寧夏醫(yī)科大學(xué)碩士研究生學(xué)位論文 英文摘要 Ⅱ The relationship of radiosensitivity and the expression

2、 of ATM and DNA-PKcs in human cervical carcinoma ABSTRACT Objective To study the relationship of radiosensitivity and expression of ATM and DNA-PKcs in human cervical carcinoma. Methods Immunohistochemistry was used

3、 to detect the expression of ATM and DNA-PKcs for 50 patients with cervical carcinoma and 20 patients with normal cervical tissue.Dased on the current radiotherapy，the patients of cervical carcinoma were divided into two

4、 groups,which were high radiosensitive and low radiosensitive .The expression of the two proteins,ATM and DNA-PKcs,were campared, and combined with clinical data, were analized the relationship with patients’ age, clinic

5、al stage and differentiation. Results (1)The positive percentages of ATM in cervical carcinoma and normal cervical tissue were 22% and 60% respectively, the differences had statistical significance(P＜0.05).(2)The posi

6、tive percentages of DNA-PKcs in cervical carcinoma and normal cervical tissue were 62% and 40% respectively, the differences had no statistical significance (P＞0.05).(3)The expression of DNA-PKcs in cervical carcinoma wa

7、s higher than ATM, the difference had statistical significance (P＜0.05).(4) In 50 cases of cervical carcinoma after radiotherapy, CR is 48% (24/50), PR is 52% (26/50).(5)The expression of ATM and DNA-PKcs in high radiose

8、nsitive group and low radiosensitive group were 8.3% and 34.6%、45.8% and 76.9% respectively, the differences of both had statistical significance (P＜0.05).(6) Spearman correlation analysis showed that the expression of A

9、TM and DNA-PKcs in cervical carcinoma had no correlation(r=0.251 P=0.078).(7)The differences of ATM and DNA-PKcs between different cervical carcinoma patients’ ages, clinical stages and differentiations had no statistic