參麥注射液對腦出血大鼠HSP70表達(dá)的影響和神經(jīng)細(xì)胞保護(hù)作用機(jī)制的實(shí)驗(yàn)研究.pdf

1、分類號：R74334密級：湖南中醫(yī)學(xué)院V7766G7編號：碩士學(xué)位論文論文題目：墨蠹垂盤盜塾墮窶壘蠢遺HSPT0塞達(dá)的型響壟進(jìn)經(jīng)細(xì)筵堡莖絲翅盔!型塑塞鑒受塞學(xué)科專鼗：主魚笙全監(jiān)盎疊簍塑登研托生姓名：童：三塞導(dǎo)師姓名及職稱：一煎澤重～塑撞一TheexperimentalStudyOfTheEffectofShenmaiInjectononTheExpressionofHeatShockProteins70(HSP70)AndThemech

2、anismofProtectiveEffectsonTheNeuronInTheRatBrainAfterIntracerebralHemorrhage(ICH)ABSTRACTWithSprapue—DewleyRatsmodelswithintracerebralhemorrhage(ICH)，ThisreseachinvestgatedtheeffectsofShenmai(SM)Injectiononthepathologics

3、ignofthenervesystem，andthepathologicchangesofthebraintissuesstructureintheareasofischemicpenumbral(IP)aroundhematomaandthehippocampalgyrusofoperatedsides，WealsoobservedtheeffectsofSMInjectionontheexpressionoftheheatshock

4、proteins70(HSP70)intheareasofhematoma、lIP、hippocampalgyrusandcotexofoperatedsidesResults：1Theeffectsonthepathologicsignofthenervesystem、thepathologicchangesofbraintissuesstructureintheareasofischemicpenumbral(IP)aroundhe

5、matomaandthehippocampaigyrusofoperatedsidesintheratsmodelswithICH，theratmodelsweremadebyinjectingCollagenasetypeVIIstereotaxicallyobeservtionwasscheduledintotburpoint(1day3day5day7dayafteroperation)，whichwasstudiedbyHEst

6、ainingandHSP70immunohistochemistryWefoudthatinthegroupsofSMInjectiontreatment，thepathologicsignsofthenervesystemwerealleviated，hematomawereabsorbedwell，thepathologicchangesofthebraintissuesstructureintheareasofIParoundhe

7、matomaandhippocampalgymsofoperatedsideswerereduced，thestructureofneuronswererelativelyimegratedTheresultssuggestedthatSMInjectionprovidedaprotectiveeffectontheneuronbyacceleratingthehematomaabsorptionandantagonizingthehy