不同手術(shù)方式對胸腺瘤合并重癥肌無力患者圍手術(shù)期血清炎性因子的影響.pdf

1、分類號：R655.5密級：不保密UDC：612.8學(xué)校代碼：11065碩士學(xué)位論文不同手術(shù)方式對胸腺瘤合并重癥肌無力患者圍手術(shù)期血清炎性因子的影響孫培道指導(dǎo)教師金利新副教授學(xué)科專業(yè)名稱人體解剖與組織胚胎學(xué)論文答辯日期2016年5月29日EffectsonThePerioperativeSerumInflammatyFactsofthymomaswithmyastheniagravistreatedbydifferentoperation

2、methodAbstractObjectiveToinvestigatetheeffectsofinflammatyreactionofthymomaswithmyastheniagravis(MG)treatedbytraditionalthacotomysutureofminimallyinvasivesurgery.MethodAtotalof40thymomaspatients(MssaokaIII)withmyasthenia

3、gravisfromAugust2014toJune2015inQiluhospitalofShonguniversityweretreatedbytraditionalthacotomy(M7F13)ascontrolgroup(n=20)videoassistedthacoscopicsurgery(VATSM8F12)astreatmentgroup(n=20).Theserumlevelsofinterleukin6(IL6)I

4、L8TumNecrosisFactα(TNFα)Creactiveprotein(CRP)CTwasmeasuredbyenzymelinkedimmunosbentassay（ELISA）methodsatbefeanesthesia（T1）afteranesthesia（T2）2hafterskincut(T3)24hpostoperation(T4)48hpostoperation(T5)72hpostoperation(T6)r

5、espectively.Operationtimebloodlosstheretaintimeofthacicductamountofpostoperativedrainagepostoperativeactivityhealingtimewerealsorepted.ThedatastatisticsanalysisbySPSS17.0softwareResultsTheserumlevelsofIL6IL8TNFαCRPCThadn

6、osignificantdifferencebetweenT1T2T2T3（t=0.114～1.860，P＞0.05）inbothcontrolgrouptreatmentgroup.Buttheserumlevelsofthesefactswereobviouslyhigherthanthatofbefetheoperationcommonlytheypeaks24hourspostoperatively（t=3.102～23.136

7、，P0.01）alsowashigheratT6thanthatofbefetheoperation（t=2.900～12.565，P0.01）exceptthelevelofTNFαrecoveredrapidllytothelevelofbefetheoperation（t=0.946，P＞0.05）intheVATSgroup.Theoperationtimepostoperativedrainagetubeindwellingt

8、imeincisionhealingtimeintheVATSwaslowerthanthatinthecontrolgroup（t=2.044～2.696，P＜0.05）.ConclusionsVATScouldbewidelyappliedinclinicalbyloweroperativetraumareducingthedegreeofinflammatyreaction.Mastergraduatestudent：Peidao