PcG家族蛋白CBX7對(duì)胃癌干細(xì)胞樣特性的調(diào)節(jié)作用與機(jī)制研究.pdf

1、後旦大學(xué)碩士學(xué)位論文學(xué)校代碼：10246學(xué)號(hào)：10211230019PcG家族蛋白CBX7對(duì)胃癌干細(xì)胞樣特性的調(diào)節(jié)作用與機(jī)制研究院系：專業(yè)：姓名：指導(dǎo)教師：導(dǎo)師組成員：完成日期：腫瘤醫(yī)院腫瘤學(xué)趙麗琴郭偉劍教授李進(jìn)教授朱曉東副教授2013年4月28日復(fù)旦大學(xué)醫(yī)學(xué)碩士學(xué)位論文PcGCBX7Oct4G1ilSox2CD44CD24CDl33CD90AktpAktP13KERKpERKMAPKJNKp161咄4A’CDKN2AmiR2lCBX7

2、iCtrliCSCsGCSCsNOD／SCIDEpCAMAUDHlERBB2，Her2PRCBmi1Mel18EZH2ESCsHSCsSPPolycombGroupChromoboxProteinHomologOctamerbindingprotein4GliomaassociatedoneogenehomologlSRYrelatedHMGboxgene2Clusterofdifferentiation44Clusterofdiffe

3、rentiation24Clusterofdifferentiationl33Clusterofdifferentiation90ProteinKinaseBPhosphorylatedproteinkinaseBPhosphatidylinosit013，，kinaseExtracellularsignal—regulatedkinasePhosphorylatedextracellularsignalregulatedkinaseM

4、itogenactivatedproteinkinaseC—JunNterminalkinaseCyclindependentkinaseinhibitor2AmicroRNA2lCBX7interferingplasmidCBX7controlplasmidCancerstemcellsGastriccancersterncellsNonobesediabetic／SeverecombinedimmunodeficiencyEpith

5、elialcelladhesionmoleculeAcetaldehydedehydrogenaselHumanepidermalgrowthfactorreceptor2polycombrepressivecomplexBcellspecificMoloneymurineleukemiavirusintegrationsitelMelanomanuclearproteinl8Enhancerofzestehomolog2Embryon

6、icstemcellsHematopoieticstemcellSidepopulation多梳基因家族染色盒同源物7八聚體結(jié)合蛋白4神經(jīng)膠質(zhì)瘤相關(guān)癌基因同源物lSRY相關(guān)的HMG盒基因2分化抗原44分化抗原24分化抗原133分化抗原90蛋白激酶B磷酸化的蛋白激酶B磷脂酰肌醇3激酶細(xì)胞外信號(hào)調(diào)節(jié)激酶磷酸化的細(xì)胞外信號(hào)調(diào)節(jié)激酶絲裂原活化蛋白激酶c—JunN末端激酶細(xì)胞周期蛋白激酶抑制物2A小分子RNA2lCBX7干擾質(zhì)粒CBX7對(duì)照質(zhì)粒腫