兩種米爾貝肟吡喹酮片內服給藥在貓的藥動學比較研究.pdf

1、兩種米爾貝肟吡喹酮片內服給藥在貓的藥動學比較研究TheComparativePharmacokineticofTwoMilbemycinOxime—praziquantelTabletsbyOralAdministrationinCats研究生：金之源專業(yè)：獸醫(yī)專業(yè)碩士導師：l＼仕金教授揚卅l大學獸醫(yī)學院2015年6月?lián)P州大學碩士學位論文TheComparativePharmacokineticofTwoMilbemycinOximep

2、raziquantelTabletsbyOralAdministrationinCatsABSTRACTMilbemycinOximehasthecharacteristicsofbroadspectruminsecticidalactivitybetterabsorptionandhighsafetyasaspecifcdrugforthetreatmentofDirofilariaimmitisandintestinalparasi

3、tesindogsandcats，whichiswidelyusedtopreventdogsandcatsfromparasitesinclinicalItiseffectivetothetreatmentoftoxocaraincatscombinedwithPraziquantelThepharmacokineticcharacteristicswereevaluatedbystudyonMilbemycinOximePraziq

4、uanteltabletspharmacokineticincatsinthispaperinordertoprovideexperimentalevidenceforthedesignofnewdrugsanditsapplicationinclinicalveterinaryandguidetherationaluseofdrugsinclinicalSixteenadultcats(8d8$)wererandomlydivided

5、intotwogroups，thepharmacokineticsoftestsubstanceandreferencesubstanceMilbemycinOximePraziquanteltabletswerestudiedincatsbyoraladministration，usingasingledoseofparalleltest(4mg／kg’bwMelbemycinOxime)TheconcentrationsofMilb

6、emycinOximeandPraziquantelinbloodplasmaweredeterminedbyhi曲performanceliquidchromatography(HPLC)methodafteradministrationanditspharmacoldneticparameterswereobtainedbyWinnonlin52softwareThemainpharmacokineticparametersofre

7、ferencesubstancewereasfollowsafteroraladministrationasaboveincatsThemeanT1／21jI，Tmax，Cmax，AUCandMRTofMilbemycinOximewererespectively2008h，600h，76443ng／mL，1500ng／L／hand1860h；ThemeanTI，2B，Tma)(，Cm“，AUCandMRTofPraziquantelw

8、ererespectively627h，388h，101825ng／mL，869ng／L／handMRT656hComparedwithPraziquantelMitbemycinOximeabsorbedandeliminatedincatswereslowlyThemainpharmacokineticparametersoftestsubstancewereasfollowsafteroraladministrationasabo

9、veincatsThemeanTl／2fj，Tmax，Cmax，AUCandMRTofMilbemycinOximewererespectively15，07h，525h，80665ng／mL，1518ng／L／hand1747h，andtherelativebioavailabilitywas10120％ThemeanT1／2p，Tmax，Cmax，AUCandMRTofPraziquantelwererespectively111l

10、h，525h，88047ng／mL，964ng／L／hand1052h，andtherelativebioavailabilitywas11916％Comparedwithreferencesubstance，theeliminationhalflifeofmilbemycinoximewassignificantlyshorterandpeaktimeofpraziquantelwassignificantlydelayed(001P