低劑量輻射對人膠質瘤細胞增殖的刺激作用及其Wnt信號機制的研究.pdf

1、低劑量輻射對人膠質瘤細胞增殖的刺激作用低劑量輻射對人膠質瘤細胞增殖的刺激作用及其及其Wnt信號機制的研究信號機制的研究何東杰培養(yǎng)類別非全日制學號2002012170學位類型學術學位一級學科(專業(yè)類)臨床醫(yī)學二級學科(專業(yè))腫瘤學研究方向膠質瘤的放射治療指導教師魏麗春教授培養(yǎng)單位西京醫(yī)院放射治療科二O一六年五月分類號R739.41UDC616密級公開第四軍醫(yī)大學碩士學位論文目錄縮略語表...........................

2、...........................................................................................................1中文摘要............................................................................................................

3、..........................2英文摘要......................................................................................................................................6前言....................................................

4、................................................................................11文獻回顧...................................................................................................................................12正

5、文...................................................................................................................................27第一部分U251人膠質瘤細胞增殖、克隆生長和Wntβcatenin信號通路分子定位.............................................

6、.......................................................................271實驗材料.................................................................................................................272實驗方法......................

7、...........................................................................................293實驗結果.................................................................................................................314討論....

8、.....................................................................................................................32第二部分低劑量輻射刺激膠質瘤細胞增殖和克隆生長作用及其Wnt信號通路干預效應...............................................................

9、........................................351實驗材料.................................................................................................................352實驗方法.....................................................

10、............................................................363實驗結果.................................................................................................................394討論...................................

11、......................................................................................40第三部分低劑量輻射對體內種植膠質瘤生長的刺激作用與Wnt信號通路干預效應................................................................................................

12、...............421實驗材料.................................................................................................................422實驗方法..............................................................................