乳腺癌芳香化酶表達與臨床病理因素的關系.pdf

1、蘇州大學碩士學位論文乳腺癌芳香化酶表達與臨床病理因素的關系姓名：李文金申請學位級別：碩士專業(yè)：普外科指導教師：趙春英20070401AssociationsbetweenaromataseexpressionandCIinicopathoIogicfactorsinbreastcancerAbstractObjective：Toinvestigatetherelationshipbetweenthearomatasegeneexpres

2、sionandclinicopathologicfactorsinbreastcancerMethods：TheexpressionlevelofaroInatasemRNAwasevaluatedbyusingofquantitativerealtimePCRin50casesofbreastcancerandnormalbreasttissuesTheratiooftumortonormaltissue(T／N)ofaromatas

3、eexpressionWaSthencalculatedforeachCaseUsingmedianofaromatasemRNAlevelinbreastcancerascutoffpointtheCaseSwerecategorizedintohighexpressiongroupandlowexpressiongroupResuRs：TheT／NratioofaromatasemRNAexpressionwassignifican

4、tlygreaterinthehormonereceptorspositivegroupthanthatinthenegativegroupp；0031)，inthegroupofpatientsolderthan50thanthatinyoungerthan50fP=O008)，andinotherpathologictypesthanthatininvasiveductalcarcinoma(P=O000)NelationshipW

5、aSfoundbetweenthe’r／Nratioandanyotherclinicopathologicfaaors，includingP53口0790)，tumorsize田=0429)，andaxillarylymphnodeinvolvementfP=O142)Conclusion：SignificantcorrelationWasfoundbetweentheT／Nratioandstatusofhormonerecepto

6、rs，ageandhistopathologyHowevernelationshipWasfoundbetweenaromatasemRNAexpressionlevelandanyotherclinicopathologicfactors，includingtumorsizeaxillarylymphnodeinvolvementandP53Bothinolderthan50groupandinhormonereceptorsposi