皮膚T細(xì)胞淋巴瘤患者的人類T淋巴細(xì)胞白血病病毒Ⅰ型感染.pdf

1、復(fù)旦大學(xué)碩士學(xué)位論文皮膚T細(xì)胞淋巴瘤患者的人類T淋巴細(xì)胞白血病病毒Ⅰ型感染姓名：高紅陽申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：生物物理學(xué)指導(dǎo)教師：?jiǎn)我追?002.5.15堡!：蘭堡堡苧堡壁!塑望壁里墮皇耋塑△鲞!鲞里塑望皂坐塹墮量三型墮!!一InfectionofHumanTLymphotropicVirusTypeIinPatientswithCutaneousTcellLymphomaAbstractCutaneousTcelllymphoma(C

2、TCL)designatesagroupofneoplasmsofTcelllymphoproliferativediseasesthatclinicallyoriginateintheskinorshowobviousmanifastationofskinlesionsItoccupies60％ofcutaneousmalignantlymphomas(CML)andshowsconsiderablevariationinclinic

3、alpresentation，histopathology，immunophenotypeandsoonTheetiologyofCTCLremainsunknownandmayberelatewithagentssuchasvirusinfection，heredity，immunityandenviromentThecourseofCTCLisslowSomestudiessuggestthatCTCLisassociatedwit

4、htheinfectionofhumanTlymphotropicvirustypeI(HTLV—I)HTLVIisakindofhumanretroviruswhichcausesadultT—cellleukemia／lymphoma(ATL／L)ThiskindofvirusisendemicinJapan，theCaribbeanregionandthewesternAfricaSincethegeographicenvirom

5、entinShanghaiandtheareasofJiang—ZhearesimilartoSouthJapanwhereHTLVIisendemic，itisinterestingwhetherthereisHTLV—IinfectionintheseareasornotInthisstudyprovirusDNAofHTLV—IandantibodiestoHTLV1weretestedamong46casesofCTCLpati

6、ents’peripherybloodwhoarelivedaroundShanghaiandJiangZheareaandnevertravelledabroadbyPCR，ELISA，PAandWesternBlot5caseswerefoundtohavepro—virusDNAofHTLVIinPBMCandamongthem3casesshowedpositivewithHTLVIantibodiesinserumThisst