膜攻擊復(fù)合物在壞死性肌病發(fā)病機(jī)制中的作用.pdf

1、軍醫(yī)進(jìn)修學(xué)院解放軍總醫(yī)院碩士學(xué)位論文膜攻擊復(fù)合物在壞死性肌病發(fā)病機(jī)制中的作用姓名：叢璐申請學(xué)位級別：碩士專業(yè)：神經(jīng)病學(xué)指導(dǎo)教師：蒲傳強(qiáng)20120522軍醫(yī)進(jìn)修學(xué)院碩士學(xué)位論文EffectofC5b9onpathogenesisofnecrotizingmyopathyAbstractObjective：ToexploretheexpressionofC5b一9intheskeletalmuscleofnecrotizingmyopath

2、y，andinvestigatethecontributionofC5b一9inpathologicalchangesofmusclefiberandbloodvesselsMethods：1The13casesofselectedpatientsfufillthecriteriaofnecrotizingmyopathy，andknowncausesofnecrotizingmyopathy，includingpolymyositis

3、anddermatomyositiswereruledout2Theclinicalandneurophysiologicalmanifestationswereanalyzedin13caseswithnecrotizingmyopathy，laboratoryexaminationincludingbloodbiochemicalandrelatedimmunologicaltestweremeasured，usingSPSS130

4、forstatisticalanalysis3TheexpressionofC5b9wasdetectedintheskeletalmuscleofnecrotizingmyopathywithenzymohistochemistryandimmunohistochemistryResults：1Among13necrotizingmyopathycases，8cases(615％)weremaleand5cases(385％)were

5、femaleTheaverageonsetageofmalepatientswas49131851andtheresultsoffemalepatientswas4841613Themainclinicalfeaturesweredesc訂bedaSfollow：weaknessoffourlimbs(846％)，weaknessofbothlowerlimbs(154％)：8patientswithneckweaknessand3pa

6、tientswithrespiratorymuscleweakness；7patientshadmyalgia，6forproximalmuscularatrophyTheaverageCKvalueofnecrotizingmyopathypatientswas46785344905，andtheaverageLDHvaluewas10222561747IU／L2Focalordispersivenecroticmusclefiber